More and more people have high uric acid?Let’s be honest: Type 1 foods you love secretly raise uric acid

2022-06-05 0 By

Zhang found that his uric acid level was 460μmol/L during his company’s physical examination last year, which was diagnosed as hyperuricemia. He did not show any symptoms, but he always attached great importance to his health, and immediately searched the Internet for ways to lower uric acid.Lao Zhang learned that “uric acid rise is caused by eating”, so he adhered to low-fat diet and basically only ate low-purine food.After half a year, Lao Zhang measured the uric acid value again, but found that the blood uric acid value increased to 510μmol/L. Lao Zhang couldn’t understand why his diet was so light, so his uric acid didn’t fall but rose.A, uric acid high are eating out?When it comes to the elevation of uric acid, some people may associate it with high-purine food and think that eating too much high-purine food will lead to the elevation of uric acid. In fact, many people misunderstand that uric acid is not necessarily related to eating.The synthesis of uric acid is composed of amino acids, carbon dioxide, phosphoribose and adenosine triphosphate (ATP), which form adenine through the action of some enzymes in the body, and finally metabolize uric acid in the body.It can be said that uric acid is a metabolite existing in the human body.The normal metabolism of purine in human body plays a stabilizing role in the fluctuation of uric acid level.A lot of people think that elevated uric acid is influenced by dietary factors.There is some truth to this, but not quite.20% of uric acid in human blood comes from exogenous purine food, but the remaining 80% comes from the body’s own metabolism.Most of the exogenous purines ingested from food are converted to uric acid, so eating a high-purine diet for a short period of time will significantly increase uric acid levels, which is why gout patients need to watch their diet.But for normal people, daily intake of purine is about 600-1000mg, if the strict control of diet, also can only reduce the blood uric acid value of about 60-120 μmol/L.Therefore, it is not a long-term solution to control blood and urine levels only by controlling diet.When the level of uric acid in the blood increases, it may precipitate in many tissues and organs, bringing various diseases: joints: a large amount of uric acid crystals deposit in the joint cavity, which can cause gout arthritis;Kidney: crystal deposition in the kidney, can induce acute and chronic uric acid nephropathy and urolithiasis;Cardiovascular and cerebrovascular: irritates and damages the blood vessel wall, increasing the risk of atherosclerotic plaque.The number of patients with hyperuricemia in China has reached 170 million and is increasing rapidly at an annual rate of 9.7 percent, according to the 2017 White Paper on the Status of Gout in China.About 20% of uric acid in human blood comes from the intake of exogenous purine food, but in some cases, it is clear that they do not eat seafood, drink laohuo soup and other high purine food, why will uric acid continue to rise?A study in the British Medical Journal found that consumption of sugary soft drinks and fructose-rich water and fruit juices was strongly associated with an increased risk of gout.Fructose is the most common hexone sugar and is found in abundance in fruit juices and honey.Zhang Youkang et al. pointed out in The Chinese Journal of Nephrology that excessive fructose intake can lead to cell phosphorylation, resulting in temporary protein synthesis disorder and the formation of excessive AMP.AMP, on the other hand, exhausts metabolic enzymes and is metabolized multiple times to xanthine, which eventually breaks down into uric acid.Therefore, for people with hyperuricemia, the following common foods containing fructose should be eaten as little as possible.Sweet drinks: all kinds of sweet drinks in the market, such as cola, milk tea, fruit juice, etc.Honey: up to 70% fructose;Fruit: mango, litchi, cantaloupe, watermelon, etc.Baking: cakes, brownies, cookies, etc.3. Does uric acid exceed 416μmol/L, but have no symptoms and need treatment?Normal adult male serum uric acid concentration is 149-416 μmol/L, more than 416μmol/L is hyperuricemia.But not all people with elevated uric acid levels have obvious symptoms.Hyperuricemia can be classified as symptomatic or asymptomatic.When uric acid exceeds its ability to dissolve, it crystallizes and accumulates in joints, cartilage and other tissues, causing pain, known as gout.Asymptomatic hyperuricemia, although the uric acid threshold is high, the solubility is relatively high, the tissue does not produce uric acid crystals, and thus does not develop symptoms.Should asymptomatic high uric acid be treated?See what domestic guides say.According to the Practice Guidelines for Patients with Hyperuricemia/Gout in China (2020), it is recommended to treat patients with blood uric acid level ≥540μmol/L or blood uric acid level ≥480μmol/L with one of the following complications:Drug therapy is recommended for asymptomatic hyperuricemia patients with hypertension, abnormal lipid metabolism, diabetes, obesity, stroke, coronary heart disease, cardiac insufficiency, uric acid nephrolithiasis, and renal impairment.Four, how much uric acid to reduce the onset of gout?The “outcome” of high uric acid is generally gout. In order to reduce the occurrence of gout, the fundamental method is to reduce uric acid. Then how much is better?A study published in the lancet rheumatology provides an answer – achieving an average serum uric acid concentration of less than 6mg/dl (less than 360μmol/L) was associated with no gout attacks in gout patients and a reduction in the number of gout attacks over the following 12 months.The standard value has, that how can help blood uric acid to reduce effectively?1. Dietary intervention and less drinks: whether healthy people or people with gout, eating food containing a lot of fructose will cause the increase of blood uric acid.The drink contains a large amount of fructose, recommended to reduce consumption.Plenty of fruit: Fruit also contains fructose, but it is also rich in potassium, vitamin C, polyphenols and other beneficial ingredients, which can reduce the risk of gout attack. It is recommended to eat fruit in moderation.More vegetables: vegetables purine content is generally less, but also alkaline urine, is conducive to uric acid discharge, it is recommended to ensure that every day 500g of all kinds of fresh vegetables.2, drug therapy to control uric acid, drug support is also very important.For patients with gout, dietary adjustment can only be used as an adjunctive treatment, and drug treatment is the most important.Diuretics, compound antihypertensive tablets, anti-tuberculosis drugs such as pyrazinamide and anti-Parkinson’s disease drugs are common drugs in uric acid treatment, and patients should take them on time according to the doctor’s advice.Uric acid is not only related to eating, and the factors affecting the excretion of uric acid are complex and diverse. Therefore, it is necessary to pay attention to the problem of uric acid and intervene as early as possible for those who lack exercise, smoke and drink, and live an irregular life.Reference: [1] “Secretly Elevated Uric acid complicity! Not hyperpurine food, this stuff is widely used in Cola, milk tea”.China Medical Tribune.2021-09-27[2] “High uric acid but not Gout, Should you take medicine?Endocrine Channel of Medical Science.2021-12-25